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Butyrate and the Bowel

Modern man has a problem with his colon, the large intestine, one’s bowels, the gut, the last processing plant in the digestive tract...

20.06.2022
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Probiotics are mostly useless and can actually hurt you

Probiotics are living micro-organisms that are taken by millions of people to boost their microbiome or to restore their gut ecosystem after a dose of antibiotics. Yet questions remain about whether they actually work.See at: https://www...

20.06.2022
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β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

Highlights •Liver BHB concentration is low in human AH, and reducing BHB in mice worsens liver injury after alcohol. •BHB supplementation reduced alcohol induced liver injury in wild-type but not Hcar2 deficient mice...

20.06.2022
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Sodium butyrate enhances the cytotoxic effect of cisplatin by abrogating the cisplatin imposed cell cycle arrest

In the present work, we studied the molecular mechanisms by which sodium butyrate sensitizes cancer cells towards cisplatin. HeLa cells were treated with 5 mM butyrate, with 8 μM cis-diaminedichloroplatinum II (cisplatin), or with both...

14.06.2022
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The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in the colon. In the last decade, multiple beneficial effects of butyrate at intestinal and extraintestinal level have been demonstrated...

08.06.2022
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Does butyrate protect from colorectal cancer?

Abstract Butyrate, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC)...

23.04.2018
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Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

The multiple beneficial effects on human health of the short-chain fatty acid butyrate, synthesized from non-absorbed carbohydrate by colonic microbiota, are well documented...

22.04.2018
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Butyrate suppresses expression of neuropilin

Read more:http://www.molecular-cancer.com/content/9/1/276

22.06.2014